Sixty-eight target genes were predicted from this 3-miRNA signature and in the functional analysis, we found that they mainly enriched ion channels and signaling pathways (calcium, notch, TRP, TGF-beta, GnRH, HIF-1, thyroid, oxytocin, mTOR and Wnt), neurotransmitter and hormone homeostasis (aldosterone, serotonin, growth hormone, dopamine and adrenaline), infectious diseases (Hepatitis, Influenza and tuberculosis) and circadian entrainment (Table 2). Here, HIF1A is linked to infectious disease.