The largest meta-analysis of XFS involved > 123,000 individuals (13,620 XFS cases, 109,837 controls) from 24 countries across six continents and identified seven loci with the strongest association signal in chromosome 15 near the lysyl oxidase-like 1 gene (LOXL1) [15, 21], which encodes a member of family of proteins involved in formation of crosslinks in collagen and elastin [22]. This evidence concerns the gene LOXL1 and exfoliation syndrome.