We also performed a subgroup analysis to further investigate the diagnostic value of CCL14 in sepsis-associated persistent severe AKI, and the results suggested that CCL14 could predict persistent severe S-AKI at T0, but not after 6 h of ICU admission, which may be related to the decay of the marker, further studies are needed to explore the change pattern of CCL14 over time. Here, CCL14 is linked to acute kidney injury.