In a recent paper, an integrated multiparametric approach demonstrated that tumor type (mainly ACTH subtype), Ki67 index ≥ 3% (Fig. 1), mitotic count > 2/10 HPF, local invasion, “grade 2” of the Trouillas’ grading, and p53 protein expression were predictor of disease recurrence or progression [15]. This evidence concerns the gene MKI67 and neoplasm.