Although Ki67 correlated with prognosis at univariate analysis [105–107], it was not an independent prognosticator at the multivariate analysis [107] suggesting that a multiparametric approach evaluating Ki67 together with tumor size, lymphatic and vascular invasion, level of wall infiltration, and immunophenotype (L-cell versus EC-cell NET) may be the best tool to identify patients at higher risk of metastasis and tumor-related death. The gene discussed is MKI67; the disease is neoplasm.