Leptin not only plays a potentially neuroprotective role by reducing cell damage related to SE induced by kainic acid (KA) [75], but also lowers the neuronal spiking in an in vitro epilepsy model and inhibits alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-mediated synaptic transmission in the mouse hippocampus [74]. This evidence concerns the gene LEP and epilepsy.