CD69 and neoplasm: In addition, the proportions of CD69+ or effector molecule granzyme B (GZMB)+ cells among tumour-infiltrating CD8+ T cells were higher in irradiated TRIM21-KO tumours (Supplementary Fig. 1k), indicating the IR-induced activation of the CD8+ T-cell antitumour immune response in TRIM21-KO tumours.