By restoring the expression of TRIM21 and VDAC2 (WT or the K135R mutant) in TRIM21/VDAC2 double-knockout NPC cells, we found that the half-life of VDAC2-K135R was significantly prolonged compared to that of VDAC2-WT (Fig. 3l). This evidence concerns the gene VDAC2 and nasopharyngeal carcinoma.