Some of the alterations identified are drivers of different tumors and for VM formation: S1PR1 (breast cancer [22]), PDGFRB, TIE-1 (melanoma [5, 23]), LOXL2 (hepatocellular carcinoma [24]) and interestingly TCF-4 (Fig. 4A). This evidence concerns the gene S1PR1 and hepatocellular carcinoma.