Because of the pivotal role of β-catenin on the stability of VE-cadherin, angiogenesis assay showed after inhibition of TNKs (as a way to down-regulated β-catenin levels) with different concentrations (XAV-939) abolish the capacity to form VM in uveal melanoma cells (Fig. 5D) and quantified by Wimasis program (Fig. 5E). Here, CDH5 is linked to uveal melanoma.