Moreover, it has been reported by different groups [47] that a small amount of cadherin (E-cadherin) can be transported to the nucleus either as a short-length [48, 49] (or cleaved) of the protein or as full length [50] by cancer cells in acetylation way, and consequently affected the β-catenin transcription activity, may represent an excellent approach to see the possible implications of VE-Cadherin acetylation in a VM context (Fig. 8). This evidence concerns the gene CDH5 and cancer.