Finally, to further explore the role of the β-catenin/VE-cadherin complex in tumor progression in metastatic uveal melanoma cells, a MUM 2B xenograft nude mice experiment showed that MUM 2B KO Y658F reduced considerably tumor growth (Fig. 6E), suggesting an essential role of VM and VE-Cad/ β-catenin axis in tumor progression. This evidence concerns the gene LXN and uveal melanoma.