MAPT and tauopathy: Experimentally, this is performed by expression of wild-type (WT) tau as a fusion to a FRET-compatible fluorescent reporter (e.g., CFP/YFP or mClover/mCerulean3) in mammalian cell lines that can be used to induce aggregation of the intracellular reporter by transfection of a recombinant or a tauopathy patient-derived seed71.