As the kidney is the most vulnerable organ in SLE, we measured the expression of DAMP receptors in kidneys from pristane-induced-lupus (PIL) mice, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), the retinoic acid-inducible gene I (RIG-I), C-type lectin receptors (CLRs), intracellular DNA sensors, and associated downstream signaling molecules. The gene discussed is RIGI; the disease is systemic lupus erythematosus.