To verify the critical role of the FAM83A-β-catenin interaction in activating Wnt/β-catenin signaling and in pancreatic cancer tumorigenesis, we identified three α-helices derived from DUF1669 of the FAM83A protein based on the PDB data (4urj) (Fig. 8a). The gene discussed is SACK1A; the disease is familial pancreatic carcinoma.