Mutations that result in the constitutively activated Wnt/β-catenin signal pathways are thought to be related to pancreatic cancer progression.4 β-catenin is the central effector that mediates the transcription activity of numerous oncogenic target genes, such as C-myc, CyclinD1, and AXIN2. The gene discussed is MYC; the disease is familial pancreatic carcinoma.