The non-receptor SRC kinase family signaling network is increasingly recognized as a key player in pancreatic tumorigenesis.38,39 Treatment of primary PDAC cultures established from patient-derived xenografts with dasatinib or PP2 reduced the clonogenic, self-renewal, and tumor-initiating capacity of pancreatic cancer stem cells (PaCSCs). Here, SRC is linked to familial pancreatic carcinoma.