Indeed, the chimeric peptide CP-FaP2 or CP-FaP3 interferes with the formation of the FAM83A-β-catenin and β-TCF4 complex, decreasing the stability of β-catenin, and counteracts the oncogenic capability of pancreatic cancer cells in vitro and in vivo. Here, NTHL1 is linked to familial pancreatic carcinoma.