LMNA and Hutchinson-Gilford progeria syndrome: Hutchinson-Gilford Progeria Syndrome (HGPS), also known as progeria, is the result of a mutation in the nuclear filament LMNA gene, leading to truncation of the Lamin A protein and, therefore, aberrant accumulation of progerin that destabilizes nuclear membranes4, ultimately causing premature aging and death5–8.