LMNA and progeroid syndrome: The Lamin A Knocked In (LAKI) mouse model of progeria carries a mutation in the lamin A gene (lmnaG609G/G609G) resulting in accumulation of the truncated form of lamin A (progerin), which causes premature aging, as evidenced by an increased number of senescent cells, progressive skeletal muscle atrophy, weight loss, abnormal Posture, marked curvature of the spine and significantly shorter life span (103 days as compared to more than 2 years for wild-type mice)31.