MYC and keratoconus: Gene set enrichment analysis (GSEA) of transcriptional profiles of multiple HKC strains plus/minus ULK3 silencing showed a strong negative correlation between ULK3 expression and gene signatures involved in KC proliferation and oncogenesis, such as increased ∆Np63, Hh/GLI and MYC signaling, as well as gene signatures related to SCC aggressiveness.