But in CRC, circPACRGL mainly promoted differentiation of N1 to N2 neutrophils by sponging miR-142-3p/miR-506-3p, N2 neutrophils increased the expression of transforming growth factor-β1 (TGF-β1), which promoted CRC cell proliferation, migration and invasion [117]. The gene discussed is TGFB1; the disease is colorectal carcinoma.