However, bendamustine combined with azacytidine displayed worse ORR and OS in AML and MDS compared with azacytidine treatment alone, indicating antagonism and higher toxicity of the two agents in this setting.685,686 Mocetinostat, also named MGCD0103, inhibits HDAC1, HDAC2, HDAC3, and HDAC11. This evidence concerns the gene HDAC1 and acute myeloid leukemia.