RUNX1T1 and acute myeloid leukemia: However, TAL1/SCL was found to be downregulated upon association with the corepressive complex of HDAC1 and mSin3A, impeding erythropoiesis.354 Regarding fusion proteins caused by chromosome translocation, PML-RARα, RUNXI-MTG8, and AML-ETO1 recruit abnormal histone-modifying enzymes to target genes, causing leukemogenesis.355 In lymphoma, various oncogenic mutations which were related with histone acetylation were also discovered.356