The most frequently mutated gene was TET2, with TET2 mutations happening in 32% (10/31) of patients with human T-cell lymphotropic virus type I (HTLV-I)-induced acute adult T-cell leukemia (ATL).228TET2 mutations also occurred in AML and T-ALL patients.229,230 In the experimental study, TET1 promoted the growth of T-ALL and could be antagonized via PARP inhibition.231. Here, TET2 is linked to acute myeloid leukemia.