DNMT3A and myelodysplastic syndrome: TET2 was associated with a normal karyotype, high WBC count, low PLT count and high age.238,255,267 Arginase 1 overexpression was related to DNMT3A and TET2 mutations in lower-grade MDS and CMML.268 Besides the genetic alteration of TET2, the expression of TET2 protein was also different between patients with hematological malignancies and healthy people.