Domatinostat, also named 4SC-202, inhibits HDAC1, HDAC2, and HDAC3, and displayed a manageable safety profile with signs of antitumor effects in a phase I trial enrolling patients with advanced hematological malignancies.687 Tacedinaline, also named CI-994, is a selective HDAC1 inhibitor and has been explored in advanced MM patients. Here, HDAC1 is linked to Miyoshi myopathy.