Domatinostat, also named 4SC-202, inhibits HDAC1, HDAC2, and HDAC3, and displayed a manageable safety profile with signs of antitumor effects in a phase I trial enrolling patients with advanced hematological malignancies.687 Tacedinaline, also named CI-994, is a selective HDAC1 inhibitor and has been explored in advanced MM patients. This evidence concerns the gene HDAC1 and hematologic disorder.