HDAC7 and acute lymphoblastic leukemia: Thus, HDAC7 downregulation was found in pro-B-ALL and BL, while its upregulation was found in pre-B-ALL and B-ALL t(8;14).382,383 HDAC7 was also shown to be essential to the survival and TCR engagement of thymic T cells during differentiation, whose overexpression was discovered in T-ALL patients.384