TET2 was associated with a normal karyotype, high WBC count, low PLT count and high age.238,255,267 Arginase 1 overexpression was related to DNMT3A and TET2 mutations in lower-grade MDS and CMML.268 Besides the genetic alteration of TET2, the expression of TET2 protein was also different between patients with hematological malignancies and healthy people. The gene discussed is TET2; the disease is chronic myelomonocytic leukemia.