H3Y41 phosphorylated by JAK2 was found to disturb the binding of the chromatin repressor HP1a and to stimulate the Lmo2 oncogene to promote leukemogenesis.355 In primary mediastinal B-cell lymphoma and Hodgkin lymphoma (HL), excessive IL-13 and the amplification of chromosome 9p24 were found to stimulate JAK2, which in turn phosphorylated H3Y41 and activated various oncoproteins, including MYC and JAK2 itself. The gene discussed is JAK2; the disease is Hodgkins lymphoma.