In NUP98-PHD (PHF23 or JARID1A) fusion AML, the PHD finger was found to read H3K4me2/3 and inhibit its removal at various lineage differentiation transcription factors, which caused persistent activation of Hox, Pbx1, and Gata3 transcription factors and led to leukemogenesis. The gene discussed is KDM5A; the disease is acute myeloid leukemia.