However, TAL1/SCL was found to be downregulated upon association with the corepressive complex of HDAC1 and mSin3A, impeding erythropoiesis.354 Regarding fusion proteins caused by chromosome translocation, PML-RARα, RUNXI-MTG8, and AML-ETO1 recruit abnormal histone-modifying enzymes to target genes, causing leukemogenesis.355 In lymphoma, various oncogenic mutations which were related with histone acetylation were also discovered.356. This evidence concerns the gene TAL1 and acute myeloid leukemia.