HDAC2 and diffuse large B-cell lymphoma: It serves as a corepressor of BCL6 and represses oncogene expression upon recruitment, impeding B-cell lymphomagenesis.377 DLBCL patients with high HDAC2 expression and low HDAC4 expression were found to display significantly worse prognosis than those with low HDAC2 expression and high HDAC4 expression, also indicating the pathogenic role of HDAC2 and the protective role of HDAC4 in DLBCL.378 HDAC6 expression varies in different malignancies, and its role is controversial.