H3Y41 phosphorylated by JAK2 was found to disturb the binding of the chromatin repressor HP1a and to stimulate the Lmo2 oncogene to promote leukemogenesis.355 In primary mediastinal B-cell lymphoma and Hodgkin lymphoma (HL), excessive IL-13 and the amplification of chromosome 9p24 were found to stimulate JAK2, which in turn phosphorylated H3Y41 and activated various oncoproteins, including MYC and JAK2 itself. This evidence concerns the gene JAK2 and B-cell non-Hodgkin lymphoma.