In NUP98-PHD (PHF23 or JARID1A) fusion AML, the PHD finger was found to read H3K4me2/3 and inhibit its removal at various lineage differentiation transcription factors, which caused persistent activation of Hox, Pbx1, and Gata3 transcription factors and led to leukemogenesis. This evidence concerns the gene NUP98 and acute myeloid leukemia.