UHRF1 and acute lymphoblastic leukemia: The UHRF1 level was found to be increased in aneuploid AML.208 The UHRF1 promoter was found to be hypomethylated in leukemia patients.209UHRF1 was found to regulate the transcriptional repressor HBP1 through MIF in T-ALL, and UHRF1-knockdown mice lived longer.210 Furthermore, difluoromethylornithine (DFMO) and thymoquinone were found to downregulate UHRF1 in Jurkat cells.211,212 UHRF1 promoted ubiquitination-mediated degradation of the tumor-suppressive promyelocytic leukemia protein.213 Berberine was a novel drug for the treatment of MM via targeting UHRF1. 202