LUNAR1 (leukemia-induced noncoding activator RNA), a NOTCH-regulated lncRNA transcript in human T-ALL, is an example of a lncRNA functioning as an oncogene in hematologic malignancies.564 LUNRAR1 is controlled by the Notch1/Rpbj activator complex and has the ability to boost IGF1R mRNA expression and maintain IGF1 signaling, hence being essential for effective in vitro and in vivo T-ALL proliferation. Here, NOTCH1 is linked to acute lymphoblastic leukemia.