TET3 and acute myeloid leukemia: TET3 mutations are infrequently observed in AML, but the expression of TET3 in HSCs and human peripheral blood T cells has been found to decrease with age.297,298 The expression of TET3 was found to be increased in AML, which was associated with poor OS and disease-free survival (DFS).223,224,227TET3 mutation could be detected in newly diagnosed AML patients.299