TDG and Miyoshi myopathy: TDG is required for embryonic development.323 DNA hypermethylation of TDG in MM cell lines was found to lead to low expression of genes, and inhibit DNA repair activity during hydrogen peroxide-induced DNA damage.324 Moreover, SUMO-1 modification and colocalization with the promyelocytic leukemia protein were required in the noncovalent SUMO-1 binding activity of TDG.325