MDM2 and neoplasm: As a functional outcome for p53 restoration, treatment with PRMT5 inhibitors significantly induced apoptosis in the above 3 cell lines (Fig. 4h and Supplementary Fig. S3b) along with increased expression of p53 (Fig. 4i) and mRNA expression of p53 target genes (MDM2, p21, and PUMA) (Fig. 4j), suggesting that PRMT5 promotes the tumor survival and growth for MCL through downregulation of p53, as illustrated in the schematic diagram (Fig. 4k).