APR-246 is a first-in-class small molecule to facilitate normal conformation and function of mutated TP53. Dose-response cytotoxicity analysis with APR-246 as a single agent displayed IC50 values above 3 μM for most MCL cell lines tested, with a poor correlation to the TP53 status (Fig. 2c). This evidence concerns the gene TP53 and mantle cell lymphoma.