In detail, KDM5A can increase the expression of P-gp, inhibit cell apoptosis and promote cell proliferation (Table 3), at the same time, overexpression of KDM5A can also promote EMT) and metastasis of paclitaxel-resistant lung adenocarcinoma cells (Fig. 11).307. This evidence concerns the gene KDM5A and lung adenocarcinoma.