KDM1A and breast cancer: As reported, John Verigos et al. found that overexpression of LSD1 increased the ability of mammary gland formation and the stem cell potential, thereby increasing the resistance of breast cancer cells to adriamycin, while knocking down LSD1 led to the opposite effect.259 In this sense, the high level of LSD1 is associated with poor prognosis in breast cancer patients (Table 2).