And the combination of GSK-J4 and cisplatin can significantly inhibit the proliferation of chondrosarcoma cells.360 Moreover, when GSK-J4 is combined with vincristine and doxorubicin, it can significantly promote the apoptosis of DLBCL.332 Interestingly, in addition to KDM6A and KDM6B, GSK-J4 also inhibited KDM2B, reduced the expression of KDM2B, and increased the H3K36 methylation levels, thereby reducing the self-renewal ability of stem cells and increased the sensitivity of cells to drugs.282. The gene discussed is KDM2B; the disease is diffuse large B-cell lymphoma.