JMJD3 can enhance neural commitment by regulating Pax6, Nestin, and Sox1 in order to influence the differentiation of Embryonic Stem Cell (ESC).223 In multiple myeloma, NF-κB pathway can upregulate KDM6B, and overexpression of KDM6B increases the expression of PRKCB and FOS genes related to MAPK pathway, thereby promoting the growth and survival of multiple myeloma cells.224 Notably, UTX is closely related to bladder cancer by affecting p53 and FGFR3 expressions.225,226. The gene discussed is NES; the disease is plasma cell myeloma.