PCGF1 can increase the expression of KDM6A, further reducing H3K27me3 level to activate the transcription of stem cell markers and promoting the proliferation of stem cells.328,329 What is more, the transcription factor GATA3, which is closely related to the poor prognosis of ovarian cancer, can recruit UTX and enhance the stemness of ovarian HGSC cells.330. The gene discussed is KDM6A; the disease is ovarian cancer.