The JMJD1 (KDM3) family: There are three proteins in the JMJD1 family, including JMJD1A (JDHM2A, KDM3A), JMJD1B (JDHM2B, KDM3B) as well as JMJD1C (JDHM2C), all of which can demethylate H3K9me1/me2 (Fig. 5).204,205 It has been reported that JMJD1A can upregulate DCLK1 and CDK6 in a demethylation-dependent manner and maintain the occurrence and development of pancreatic cancer.206,207. This evidence concerns the gene KDM3B and familial pancreatic carcinoma.