KDM2A knockdown can lessen its downstream SOX2, NANOG, and OCT4 to reduce the formation of tumor stem cells and decrease the resistance to sorafenib (Table 3).281 Another member of the KDM2 family, KDM2B, also plays a significant role in the regulation of stem cells, thereby regulating cell sensitivity to drugs. This evidence concerns the gene KDM2A and neoplasm.