It has been reported that low expression of KDM5D can promote the metastasis of gastric cancer cells by inducing EMT and demethylating H3K4 on CUL4A promoter (Fig. 11).320 Besides, Komura et al. indicated that the deletion or decrease of KDM5D is the major cause of docetaxel resistance. This evidence concerns the gene KDM5D and gastric cancer.