PHF8 and cancer: The KDM7 family: In KDM7 family, it is generally believed that KIAA1718 (KDM7A) and PHF8 (KDM7B) can participate in demethylating H3K27me1/2, H3K9me1/2 and H4K20me1 and promoting cancer progress (Fig. 5), while PHF2 is considered to inhibit tumor growth.227,228 Specifically, PHF8 is generally elevated in hepatocellular carcinoma (HCC), which is directly related to the occurrence and migration.229 Besides, PHF2 can modulate the expression of cell cycle-related genes and regulate DNA replication.230