CDKN1A and neoplasm: Moreover, the deletion of KDM2B also increased the apoptotic cells by inducing the expression of p21CIP1/WAF1 and cleaved PARP, thus making cells more sensitive to chemotherapeutic agents (Table 3).282 Besides, inhibition of KDM2B in GBM led to a higher expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and reduced tumor growth and angiogenesis in mice (Fig. 9).283