Negatively correlated with TLX and positively correlated with laminin-integrin α6, upregulation of TET3 is able to increase the levels of tumor suppressor genes, thereby inhibiting the growth and self-renewal ability in glioblastoma stem cells.64,65 Regulation of stemness is perhaps responsible for the reduction of glioblastoma resistance induced by TET3, however, the underlying mechanisms of TET3-regulated drug resistance in other cancers require further investigation. This evidence concerns the gene TET3 and neoplasm.