UHRF1 and acute myeloid leukemia: KDM4C can increase the expression of MALAT1 and MALAT1 inhibits its downstream miR-328-3p expression, and then activates cyclin CCND2, making the acute myeloid leukemia (AML) cells resistant to cytarabine (Fig. 10, Table 3).299 In addition, UHRF1 can recruit KDM4C and further regulate the transcription of CDC6 through the demethylation of H3K9 by KDM4C, which is crucial for cell resistance.300 Similar to the function of LSD1, KDM4C, and KDM4D are also necessary for the maintenance of cancer stem cell.