For example, MEG3 can upregulate p53 and promote the binding of p53 to the promoter of growth differentiation factor 15 (GDF15), thereby inhibiting tumor growth.94 On the contrary, as an oncogene, lncRNA HOX transcript antisense RNA overexpression can increase the metastatic and invasive abilities in various tumors.95,96. The gene discussed is TP53; the disease is neoplasm.