GSK-J4 can inhibit the expression of Notch2, thereby increasing the sensitivity of colorectal cancer to oxaliplatin.329 Significantly, GSK-J4 can cooperate with 5-FU to inhibit the proliferation of colorectal cancer and reduce cell stemness, thus increasing sensitivity.359 In addition, Lhuissier et al. found that chondrosarcoma is resistant to both radiotherapy and chemotherapy. This evidence concerns the gene NOTCH2 and colorectal cancer.