KDM1A and breast cancer: LSD1 is an important histone demethylation enzyme and can regulate the drug resistance of various cancer cells by changing the methylation levels of H3K4 and H3K9.181,182 Satoi Nagasawa et al. found that the increased LSD1 mRNA level is a potential prognostic factor of poor prognosis in basal-like breast cancer, and the increased expression of LSD1 protein is related to the poor prognosis of triple-negative breast cancer.253