Although JARID2 does not have demethylase activity, it can affect the cell stemness by increasing the expression of Notch1 and promoting resistance of non-small lung cell to cisplatin (Table 3).339 Interestingly, JARID2 was downregulated in glioblastoma, and JARID2 overexpression could reduce CCND1 expression and promote apoptosis after treated with temozolomide.340. Here, JARID2 is linked to glioblastoma.