KDM4D and cancer: When the expression of KDM4C was decreased, the migration and spheroid formation ability of cells was reduced, and the CSC property was inhibited.302 And it has been proved that JMJD2D can enhance the transcription of EpCAM and Sox9, which are the target genes of Wnt/β-catenin signaling pathway and Notch signaling pathway, thereby promoting the self-renewal ability of liver cancer stem-like cells (LSCS) (Fig. 10).303 Although the role of KDM4D on drug resistance is clear in hepatocellular carcinoma, the drug resistance mechanisms of KDM4D in other cancers are less studied.