TNF and rheumatoid arthritis: Enbrel (etanercept) relieves inflammation in RA patients by binding tumor necrosis factor (TNF).373–375 Humira (adalimumab) is also working as a tumor necrosis factor (TNF) blocker,376–378 and Remicade (infliximab) blocks the activity of TNF-α.379–381 In addition, Simponi (golimumab) binds to both the transmembrane and soluble bioactive forms of human TNF-α, thus preventing TNF-α binding to its receptors382–384 in the case of treating RA.