We also hypothesized that NAV2 might affect inflammation during RA disease progression and the cell-cell interaction in sensitizing joint-innervating neurons that contribute to arthritis pain.257 Although our studies first indicate that inhibition of NAV2 expression prevents RA progression and reverses inflammation-related phenotypes, we proposed that NAV2 is a novel promising intervention target for RA treatment. This evidence concerns the gene NAV2 and arthritic joint disease.