IL6 and arthritic joint disease: In the CIA mouse model,443 Zebularine produced a sustained reduction in the severity of arthritis and promoted the generation of Treg.444 Epigallocatechin-3 gallate (EGCG) inhibits MMP-2, IL-6, and IL-8 production and selectively inhibits COX2 expression in human RAFLS.445 Importantly, these drugs have been shown to inhibit the activation of DNMTs in RA-related studies.