This study is the first time to demonstrate that GATA4 plays a key role in regulating VEGF from RA FLS to induce cell migration, promote cell proliferation, and the formation of angiogenic tubes.282 In addition, this study provided evidence that GATA4 has a previously unknown function as a modulator of RA angiogenesis, and data validate GATA4 as the therapeutic target in RA mice. This evidence concerns the gene VEGFA and rheumatoid arthritis.