HDAC6 and arthritic joint disease: Additionally, Our research has revealed that the hydrogen sulfide (H2S) donor S-propargyl-cysteine (SPRC, named also as ZYZ-802) could alleviate inflammatory response and inhibit HDAC6 expression in vivo via the HDAC6/MyD88/NF-κB signaling pathway,300 or Nrf2-ARE signaling pathway.462 At the same time, we also found that CSE/H2S can reduce the expression of JMJD3 by inhibiting transcription factor SP-1 and alleviating arthritis.463 SPRC might serve as a potential drug for RA treatment.