It has been reported that inhibition of NF-κB can inhibit inflammation, angiogenesis, pannus formation, leukocyte maturation, and activation, and osteoclast differentiation, targeting HIF-1α can induce dysregulation of MMP production, inflammatory cell recruitment, and angiogenesis, inhibition of AP-1 can inhibit the production of MMP-1, MMP-3, MMP-9, MMP-13, and IL-1β.271,281 New agents that regulate transcription factor pathways will be potential candidates for treating RA. This evidence concerns the gene MMP3 and rheumatoid arthritis.