KDM6B and rheumatoid arthritis: This evidence provides novel ideas for RA treatment.301,302 Our team also found that in PDGF-induced FLS, the expression of the Jumonji C histone demethylase family (JMJD3) is increased through the Akt signaling pathway, meanwhile, the migration and proliferation ability of FLS is weakened after inhibiting or silencing of JMJD3.