This evidence provides novel ideas for RA treatment.301,302 Our team also found that in PDGF-induced FLS, the expression of the Jumonji C histone demethylase family (JMJD3) is increased through the Akt signaling pathway, meanwhile, the migration and proliferation ability of FLS is weakened after inhibiting or silencing of JMJD3. The gene discussed is AKT1; the disease is rheumatoid arthritis.