GRIN2A and schizophrenia: Integrating these different streams of evidence, we assumed that the common schizophrenia-associated intronic variants of GRIN2A lead to reduced expression of the NR2A subunit, which should particularly affect Parvalbumin-positive interneurons and thus cause a disinhibition of glutamatergic pyramidal cells (Fig. 1d) as suggested both by pharmacological models of schizophrenia and the phenotype of exonic GRIN2A loss of function variants.