RGS12 contains multiple functional domains that may act as scaffolds to activate the target proteins by post-modifications such as phosphorylation, ubiquitination, and SUMOylation.25–30 We previously found that RGS12 promotes the phosphorylation and SUMOylation of PTEN to repress cancer cell proliferation and migration.25 However, it is unclear whether RGS12 is expressed in TAMs and controls anti-tumor immunity by affecting cilia. This evidence concerns the gene RGS12 and cancer.