FN1 and cancer: For instance, hyperbaric oxygen (HBO) promotes PD-1 antibody delivery and T cell infiltration into the cancer parenchyma by depleting major components of the extracellular matrix, such as collagen and fibronectin.429 Genetic engineering approaches can be used to construct high-affinity NK (haNK) cells, which can express high-affinity CD16 receptors and IL-2, improve tolerance against acute hypoxia, and maintain the functions of NK cells to kill cancer cells.430