EGLN3 and neoplasm: Under hypoxic conditions, PHD3 loss reduces ACC2 hydroxylation and promotes FAO to provide energy.173,174 SCD is a membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated FA (MUFA) from saturated FA, promotes tumor progression, and is associated with tumor recurrence and poor prognosis.175–177 The main products of SCD are palmitoleic and oleic acids, providing key substrates for the production of complex lipids such as triglycerides, phospholipids, and cholesterol esters.