ARNT and cancer: To survive under hypoxic conditions, cancer cells reprogram their metabolism, protein synthesis, and cell cycle progression through the synergy of transcription factors.79 One of the main reasons why cancer cells can survive in hypoxic environments is the activation of HIFs, which reprogram metabolism, protein synthesis, and cell cycle progression.79,80 The HIF family has two distinct subunits: α (HIF-1α, HIF-2α, and HIF-3α) and β (HIF-1β).