ACLY is responsible for catalyzing the conversion of citrate and CoA to acetyl-CoA and oxaloacetate.169 Studies have suggested that miR-27 and miR-195 are also upregulated in hypoxia-induced cardiomyocytes, suppressing the expression of ACLY and ACC.170,171 The mechanism of ACLY regulation in tumor cells under hypoxic conditions is still unclear. The gene discussed is ACLY; the disease is neoplasm.