HIF1A and cancer: However, the associated mechanism should be investigated.319 Neutrophils have an extensive mitochondrial network that uses the glycolytic product (glycerol-3-phosphate) to maintain polarized mitochondria and produce ROS to regulate HIF-1α stability.320 Neutrophil extracellular traps (NETs) promote cancer cell colonization by enhancing migration, invasion and cancer cell stemness, leading to poor cancer prognosis.