TPX2 and cancer: Based on these results on the well-known nuclear localization of TPX2 in interphase (37, 38) and its frequent co-overexpression with AURKA in tumors (references 39, 40; see heatmap profiles and tissue-wise expression in different cancer types compared with normal tissues in Fig 3C and D), we hypothesized that TPX2 influences the AurkA nuclear pool and that it may directly contribute to the increased nuclear localization of the kinase observed in certain cancer types (22).