This effect of CXCR3 blockade was related to decreased infiltration of CD431B11+CD8+ T cells in the TME as well as reduced tumor-infiltrating NKG2A+CD8+ T cells and tumor-specific CD8+ T cells, while the CD431B11+CD8+ and NKG2A+CD8+ T cells were unaffected in the blood circulation (Figures 7K and S7C). This evidence concerns the gene CXCR3 and neoplasm.