TNFRSF4 and neoplasm: ,13,14 In addition, methods directly targeting costimulatory receptors, such as members of the tumor necrosis factor receptor (TNFR) superfamily (e.g., CD27, CD134 [OX40], and CD137 [4-1BB]) expressed on tumor-specific T cells, have been developed and shown potential by itself and combined with immune checkpoint blockade.15