Strikingly, tumor-specific CD8+ T cells recognizing the neo-epitope ASMTNMELM from Adpgk, expressed by MC-38 tumors,43 and the tumor antigens Trp2 and M8, expressed by HCmel12 tumors, were increased in the blood circulation, and these tumor-specific T cells highly expressed CD431B11 (Figures 2E, S2E, and S2F). This evidence concerns the gene CD8A and neoplasm.