In the tumor-draining lymph node (tdLN) and bone marrow, significantly higher frequencies of CD431B11+CD4+ T cells but not CD431B11+CD8+ T cells in the PDOX treated mice were detected, and these cells differentially expressed ICOS, CD38, CD39, and KLRG1 (Figures 4C and S3). This evidence concerns the gene ICOS and neoplasm.