BMAL1 and glioblastoma: Intriguingly, the sensitivity of human and murine GBM cells to the TMZ-induced DNA damage, apoptosis, and growth inhibition was shown to be the most pronounced around the peak of BMAL1 expression, that is in the morning for both humans and mice (housed under a 7AM lights-on, 7PM lights-off schedule, mimicking human light exposure).60