AGT and hypertensive disorder: Sodium thiosulfate (STS), a major metabolite of H2S with strong antioxidant and vasodilatory activity, has been proven safe for the treatment of calciphylaxis, renal hypertension, cyanide poisoning, and cisplatin toxicity, cerebral vasospasm, angiotensin II-induced hypertension, renovascular hypertension and improving renal function in hyperoxaluric rats [11–18].