Our data informed that an upregulation in Drp-1, a downregulation in OPA-1 and an increased release of cytosolic cytochrome c were noted in the CKD kidney, whereas STS treatment efficiently recovered the Drp-1, OPA and cytosolic cytochrome c expression toward normal status, implicating the role of STS in preservation of mitochondrial dynamics and integrity. Here, OPA1 is linked to chronic kidney disease.