Recent studies suggest a measles-induced immune amnesia that could have long-term immunosuppressive effects via preferential depletion of memory CD150+ lymphocytes.1–3 An association with a 2–3-year period of increased mortality and morbidity from infectious diseases other than measles has been shown in children from wealthy countries,4–6 and increased morbidity of clinical signs of infectious disease was shown in children 9–59 months of age in the Democratic Republic of the Congo (DRC) who had been classified as measles cases within the past 2 years.7 The gene discussed is SLAMF1; the disease is measles.