PTGS2 and posterior cortical atrophy: Among these targets, PTGS1, a key enzyme in the synthesis of prostaglandin connected by 41 compounds, is involved in maintaining tissue homeostasis and cellular signaling, while PTGS2 with the highest number of compound-target interactions (Degree = 68), affects PCa progression and development, mainly regulated by neovascularization and increased resistance to apoptosis [40–42].