Complete cathepsin inhibition did not prevent caspase cleavage (Figure 4C) and did not rescue DC661-induced cytotoxicity in short-term and long-term viability assays in melanoma (Figure 4, D and E), colon cancer, and pancreatic cancer cells (Supplemental Figure 6, A–C). The gene discussed is CTSS; the disease is malignant colon neoplasm.