Through binding motif analysis, cross-referencing with ChIP-Seq data from luminal breast cancer cells, and unsupervised hierarchal clustering, we confirmed that a FOXM1 target gene signature including many key regulators of the G2/M phase and mitotic progression was notably repressed in organoids lacking c-Src (Supplemental Figure 4B). The gene discussed is FOXM1; the disease is breast carcinoma.