LDLR and Hypercholesterolemia: In LDL-receptor knockout mice (Ldlr -/-), a 4 week WD induces hypercholesterolaemia, systemic inflammation, and activation of the innate immune system.72 Four subsequent weeks of chow diet following the WD completely normalizes the systemic inflammation, but leaves the myeloid cells in a persistent hyperresponsive phenotype upon restimulation with TLR ligands.