RAG2 and colitis: Whereas IBD and CRC share certain specific dysbiotic profiles, including increases in Escherichia coli and Enterotoxigenic Bacteroides fragilis, Fusobacterium nucleatum appears to be more associated with CRC.106–108 An earlier study found that Fusobacterium nucleatum does not trigger colitis and exacerbate colon inflammation in APC (Min/+) mice, nor aggravate intestinal inflammation and induce tumors in colitis models of IL-10(-/-) and T-bet(-/-)/Rag2(-/-) mice.109 This implies that the tumorigenesis of Fusobacteria-mediated tumor progression may be less associated with inflammation.