In addition, Table 2 demonstrates the statistically significant increase (p < 0.000) found in the median salivary levels of each salivary biomarker, i.e. TNF-α and caspase-1, in the periodontitis group (151.036 pg/ml and 3.022 ng/ml, resp) when compared to the control group (82.768 pg/ml and 1.298 ng/ml, resp). This evidence concerns the gene CASP1 and periodontitis.