In addition to the presence of nuclear Tfeb in renal cysts (Fig. 2, A and D), a similar and pronounced nuclear translocation of Tfe3, another melanocyte-inducing transcription family member, was observed in cyst epithelia in both Flcnfl/fl:Ksp-Cre (Fig. 2B) and Fnip1/2fl/fl:Ksp-Cre double KO (Fig. 2E) models compared with control tubular epithelia (Fig. 2, G and H). This evidence concerns the gene TFEB and cystic kidney disease.