In the current study, by in vitro study, we confirmed that over expression of TUG1 could significantly reduce the Collagen IV and fibronectin expression in HG-treated HK2 cells; Meanwhile, by AAV-TUG1 lentivirus vector delivery, we also confirm that exogenous TUG1 administration also significantly improve the renal function and ameliorate the interstitial fibrosis in DN mice. Here, TUG1 is linked to liver dysplastic nodule.