Song et al.172co‐delivered VEGF siRNA (siVEGF) and PIGF siRNA (siPIGF), which were up‐regulated in both bulk tumor cells and TAMs, using polyethylene glycol (PEG) and mannose doubly modified trimethyl chitosan (PEG = MT) along with citraconic anhydride grafted poly (allylamine hydrochloride) (PC)‐based nanoparticles (NPs) (PEG = MT/PC NPs) with dual pH‐responsiveness. The gene discussed is VEGFA; the disease is neoplasm.