The selective maturation of miR‐6769b‐3p and miR‐499a‐3p in a METTL14‐mediated m6A‐dependent manner led us to hypothesize that miR‐6769b‐3p and miR‐499a‐3p may regulate METTL14‐controlled glycolysis reprogramming in p53‐WT CRC cells. Here, TP53 is linked to colorectal carcinoma.