Besides, METTL14 expression was transcriptionally regulated by wild‐type p53 and METTL14‐mediated m6A modification selectively promoted miRNAs maturation in a YTHDF2‐dependent manner, thereby inhibiting Warburg effect in p53‐WT CRC by targeting SLC2A3 and PGAM1, respectively. Here, SLC2A3 is linked to colorectal carcinoma.