APC and cancer: Colorectal cancer (CRC) is the third leading cause of death among various cancers and is attributed to a series of mutational events including the adenomatous polyposis coli (APC), Kirsten rat sarcoma 2 viral oncogene homolog (KRAS), B‐Raf proto‐oncogene, serine/threonine kinase (BRAF), and tumor protein P53 (p53) (Walther et al, 2009; Siegel et al, 2021).