Further, we confirmed that miR‐6769b‐3p/miR‐499a‐3p up‐regulation suppressed p53‐WT tumor growth in vivo (Fig 4N), while xenograft tumors from p53‐MT CRC cells expressing control or miR‐6769b‐3p/miR‐499a‐3p exhibited no significant differences (Fig 4O). This evidence concerns the gene TP53 and colorectal carcinoma.