Although researchers have developed chromopynones, glutor, glupin, and NV‐5440 as small‐molecule inhibitors of SLC2A3, and MJE3, EGCG, 14r, PGMI‐004A, and HKB99 have been reported as potential PGAM1 inhibitors (Huang et al, 2019a; Reckzeh & Waldmann, 2020), these inhibitors are less specific or their applications in CRC have not been widely reported. Here, PGAM1 is linked to colorectal carcinoma.