Moreover, the top METTL14 co‐dependencies include not only p53 and the p53‐positive modulators ATM and TP53BP1, as well as p53 main effector p21WAF1/Cip1 (with Achilles score positively correlated with that of METTL14) but also p53‐negative modulators MDM2 and PPM1D (with Achilles score negatively correlated with that of METTL14) in p53‐WT cancer cells lines or whole cancer cell lines, whereas the significant correlations between METTL14 and p53 disappeared, and the correlations between METTL14 and regulators and effector of p53 tended to get weak in p53‐MT cell lines (Fig 6E). The gene discussed is TP53; the disease is cancer.