METTL14‐mediated m6A modification selectively promotes YTHDF2‐dependent processing of pri‐miR‐6769b and pri‐miR‐499a, which facilitates the maturation of corresponding miRNAs that target SLC2A3 and PGAM1, respectively, thereby inhibiting glycolysis in p53‐WT CRC. The gene discussed is PGAM1; the disease is colorectal carcinoma.