EVA1A and atherosclerosis: Although Li et al20 reported increased atherosclerosis in EVA1A whole-body knockout mice, they did not study the function of endothelial EVA1A in vivo which would have required an EC-specific EVA1A knockout, due to EVA1A ubiquitous expression and contribution of multiple cell types to atherosclerosis development.66,67 Additionally, it remains to be shown whether the protective role of EVA1A in the endothelium involves autophagy.