Cardiomyocyte-specific knockout of EVA1A in mice led to rapid heart failure by impairing autophagy.18 EVA1A may also be involved in regulation of plaque stability as increased EVA1A mRNA expression was found in symptomatic compared to asymptomatic human carotid plaques.19 Whole-body EVA1A knockout in mice was protective against atherosclerosis20; however, the underlying mechanism including the potential role of autophagy regulation is incompletely understood. This evidence concerns the gene EVA1A and heart failure.