In the present study, proteomic analysis of kidney tissues from CI-AKI rats identified differentially expressed proteins, including KIM1, TIMP2, IGFBP7, L-FABP, AGT, UMOD, DKK3, TFF3, and Clusterin, which are good predictors of acute kidney injury in other studies [35,36]. The gene discussed is TFF3; the disease is acute kidney injury.