Laudes et al. (2009) recently found that human fetal adiponectin and retinol‐binding protein (RBP)‐4 levels are related to birth weight and maternal obesity, with adiponectin being more likely to have a role in perinatal priming of obesity and insulin resistance than RBP‐4. This evidence concerns the gene RBP4 and obesity due to melanocortin 4 receptor deficiency.