Later, Gao et al. (2016) and Gwon et al. (2021) further confirmed the implication of necroptosis in CP-induced AKI where pharmacological inhibition of RIPK1/RIPK3/MLKL axis by protocatechuic aldehyde and 6-shogaol, respectively significantly attenuates renal injury. Here, RIPK1 is linked to acute kidney injury.