SFN and acute kidney injury: More recently, Yang et al. (2019); Yang et al. (2021) and Wang F. et al. (2022) showed that Smad 2/3 and stratifin proteins play a detrimental role in CP-induced AKI by inducing necroptosis and necroinflammation, and interestingly, targeting these proteins suppressed the necroptosis signaling and thereby alleviating AKI.