SMAD7 and osteoporosis: In addition, Tao et al. used prednisone to induce zebrafish osteoporosis model, and found that compared with raw ABR, salt processed ABR could significantly increase the amount of bone mineralization in zebrafish osteoporosis model, and significantly up-regulated the expression levels of transforming growth factor-β, p-Smad2/3 and Smad four proteins, down-regulated the expression levels of Smad7 protein, and the therapeutic effect of salt processed ABR was better than raw ABR (Tao et al., 2020).