The genomic region, including the Itih3 locus, is associated with schizophrenia and bipolar disorder (Cardno and Owen, 2014), and Itih3 is listed in the second highest group, which shows constant expression changes in different stress-induced depression models with Etnppl (Flati et al., 2020), suggesting the involvement of Itih3 in psychiatric diseases. Here, ITIH3 is linked to bipolar disorder.