A transcriptomic study reported ETNPPL as one of the top genes upregulated in schizophrenia or bipolar patients (Shao and Vawter, 2008), and a re-analysis of 751 transcriptomic samples of stress-induced depression models identified Etnppl as the second highest group that showed constant expression changes in different samples (overlap among 18 BioProjects is 5) (Flati et al., 2020), suggesting that Etnppl is involved in psychiatric diseases. This evidence concerns the gene ETNPPL and depressive symptom measurement.