Specifically, in Gaucher disease, the accumulation of glucosylceramide and glucosylsphingosine in macrophage leads to macrophage activation-mediated release of various cytokines (i.e., chitotriosidase, TNF-a, IL-1b) (28), while there is also lysosomal dysfunction-mediated trigger of auto-inflammatory cascades involving a broad spectrum of myeloid cells, cytokine/chemokine secretion and NLRP3 inflammasome activation (23, 32). The gene discussed is TNF; the disease is Gaucher disease.