BSJ-03-123 highlighted that global transcriptional and signalling effects of CDK6 are mainly via its kinase activity.169 In AML cell lines BSJ-03-123 efficacy was dependent on INK4 status.81 As previously mentioned, p16INK4a has been shown to confer resistance to palbociclib treatment when highly expressed, however p16 does not necessarily sensitise cells to palbociclib when at low levels. This evidence concerns the gene CDKN2A and acute myeloid leukemia.