ACTA1 and hydrops fetalis: Furthermore, Tan IIA has been suggested to reverse increased levels of collagen type 1 (Col1) and collagen type 3 (Col3), and growing α-smooth muscle actin (α-SMA) in TGF-β1 stimulated cardiac fibroblasts (CFs) and acute myocardial infarction (AMI) or HF rats induced by ligating left anterior descending branch (LAD) of the coronary artery through upregulating miR-205-3p [145], miR-29b [146], or miR-618 [147].