ARs located and dispersed all around the brain areas regulates the release of neurotransmitter and the action of neuromodulators, which include both inhibitory and excitatory functions. Research suggests possible implication of adenosine symptoms in panic/anxiety-inducing substances. PD sufferers are more sensitive to anxiety-inducing substances, which includes lactic acid injection, elevated CO2 levels, caffeine, yohimbine, m-cholorophenulpiperazine, CCK, nicotine, alcohol, epinephrine, norepinephrine, and sodium lactate. Here, CCK is linked to Anxiety.