ANGPTL4 and neoplasm: Angiopoietin-like 4 (ANGPTL4) encodes a glycosylated secreted protein that acts as a serum hormone to regulate blood glucose homeostasis and lipid metabolism; meanwhile, the encoded protein can serve as an apoptotic survival factor for vascular endothelia cells that may prevent metastasis by inhibiting vascular growth and tumor cell invasion [21, 22].