TP53 and escherichia coli infection: Among these, eight pathways were associated with the LR group, such as valine leucine and isoleucine degradation, taste transduction, and nitrogen metabolism; six pathways were closely corrected with the HR group, including the P53 signaling pathway, pathogenic Escherichia coli infection, ubiquitin-mediated proteolysis, the proteasome, pyrimidine metabolism, and pancreatic cancer (Figure 6).