For example, in COPD tissues, the low-expressed lncRNA, SNHG5, is closely involved in low-forced expiratory volume in one second (FEV1%) in patients via the miR-132/PTEN axis, which regulates human bronchial epithelial cell inflammation and apoptosis in COPD (Shen et al., 2020). Here, PTEN is linked to chronic obstructive pulmonary disease.