IL17 also induces an increase in osteoclasts not only by stimulating the secretion of IL6 and RANKL, but also by altering the microbial composition of the oral cavity, increasing levels of Enterobacteriaceae, Enterococcus and Staphylococcus, which can aggravate periodontitis (Xiao et al., 2017). This evidence concerns the gene TNFSF11 and periodontitis.