Another study found different epigenetic profiling of CD8+ T cells and CD4+ T cells in MS patients (Maltby et al., 2015; Kiselev et al., 2022), and the same authors indicated hypomethylation in CD4+ T cells at HLA-DRB1 and HLA-DRB5 hypermethylation in a MS cohort (Maltby et al., 2017). The gene discussed is HLA-DRB5; the disease is myeloid sarcoma.