Roostaei et al. studing the DNA methylation profiles of primary CD4+ T-cells from MS patients, disclosed a broad map of cis-mQTL (methyl quantitative trait), and identified 19 M susceptibility loci with colocalised cis-mQTL effects, such as the TBX6 locus, which also has an effect in trans. This evidence concerns the gene CD4 and myeloid sarcoma.