Furthermore, we found that PPARG, also known as peroxisome-proliferator receptor-γ (PPARγ), which modulates cellular response to DNA damage and make cancer cells resistant to cytotoxic chemotherapy 58, acted as the downstream target of MORC2 SUMOylation to participate in the DNA damage repair process (Figure S9B-C). The gene discussed is MORC2; the disease is cancer.